Alpha Pharma Promifen 50 tablets 50mg/tab

Description

Clomid (Clomiphene Citrate) falls under the category of drugs known as selective Estrogen receptor modulators (SERMs), which are a subset of anti-estrogens. The broader classification of anti-estrogens encompasses aromatase inhibitors (AIs) like Aromasin (Exemestane) and Arimidex (Anastrozole). While both AIs and SERMs are anti-estrogens, they function differently in managing estrogen levels.

Contrary to a common misconception within the steroid-using community, SERMs such as Nolvadex and Clomid do not reduce estrogen levels in the bloodstream. Instead, they obstruct estrogen's action by binding to receptor sites in breast tissue, preventing estrogen from exerting its effects there. However, SERMs also act as estrogens in other bodily tissues, like the liver in Nolvadex's case.

Clomid, initially developed in the early 1970s for treating female infertility, has gained widespread use globally, akin to Nolvadex, due to its availability and affordability. Despite its classification as an anti-estrogen, Clomid primarily serves as a non-steroidal ovulatory stimulant for women experiencing ovulation failure. Unlike Nolvadex, Clomid exhibits weaker estrogen-blocking activity in breast tissue, making it less effective for that purpose. However, it shares with Nolvadex the ability to act as an estrogen agonist or antagonist in various body tissues.

In both males and females, Clomid's antagonistic effect on the hypothalamus stimulates the release of hormones like LH and FSH, essential for testosterone production in men and follicular rupture in women. This action makes Clomid valuable for restoring hormonal balance post-anabolic steroid use, especially during post-cycle therapy (PCT) when combined with Nolvadex and HCG.

Clomid, like Nolvadex, also demonstrates estrogen agonistic effects in the liver, benefiting cholesterol levels. This underscores the importance of maintaining estrogen levels for overall health, as excessive reduction through aromatase inhibitors can adversely affect cholesterol profiles.

Chemically, Clomid is a non-steroidal SERM with both agonistic and antagonistic properties towards estrogen. While its primary medical application is in female fertility treatment, it also finds use among males.

Despite its efficacy in preventing and reversing early-stage gynecomastia, Clomid's primary role among steroid users is stimulating endogenous testosterone production. However, research suggests Nolvadex may offer advantages over Clomid in this regard.

As a SERM, Clomid does not address other estrogenic side effects like bloating or acne, focusing primarily on breast tissue estrogen activity. Other side effects related to increased blood plasma estrogen levels are not mitigated by Clomid or other SERMs.